- Case Report
- Open Access
- Open Peer Review
Endovascular management of unruptured intercostal artery aneurysms
© The Author(s) 2019
- Received: 19 September 2018
- Accepted: 27 December 2018
- Published: 4 January 2019
Intercostal artery aneurysms are rare vascular abnormalities that are typically diagnosed following rupture in patients with predisposing conditions. Our report is the first to document a patient with unruptured intercostal artery aneurysms in the absence of any associated disease.
A 70-year-old male with prostatic adenocarcinoma was incidentally discovered to have multiple unruptured aneurysms of his intercostal arteries. Three of the aneurysms were embolized utilizing microcoils and glue. At six-month follow-up the patient remained asymptomatic.
We demonstrate successful endovascular management of a unique case of multiple idiopathic unruptured intercostal artery aneurysms. Appropriate diagnosis and prompt treatment of these rare vascular lesions is essential in preventing the potentially catastrophic consequences of rupture.
- Intercostal artery
- Endovascular procedure
Intercostal artery aneurysms are rare vascular abnormalities that are most often associated with aortic coarctation or neurofibromatosis type 1 (Tapping & Ettles, 2011; Dominguez et al., 2002). Aneurysm formation can also represent sequelae of vascular injury from systemic vasculitis, local infection, prior iatrogenic intervention, or previous trauma (Gonzalez et al., 2011; Bonne et al., 2015; Hernandez-Velasquez et al., 2016; Neuwirth & Singh, 2010). Patients with intercostal artery aneurysms are usually diagnosed following rupture, a potentially life-threatening complication (Arai et al., 2007; Kim et al., 2011). We describe a unique case of a patient who was incidentally found to have multiple unruptured intercostal artery aneurysms of indeterminate etiology. The clinical presentation, radiologic imaging, and endovascular management are discussed.
The cause of intercostal artery aneurysm formation in this case remains unknown as no clinical or radiological evidence of any associated disease was identified. The presence of intercostal artery aneurysms in the absence of a predisposing condition is described in just two other case reports in the literature (Topel et al., 2004; Carr et al., 2013). As both of these patients presented with acute chest and back pain due to hemothorax, our report is the first to document idiopathic intercostal artery aneurysms prior to rupture. Thus, this is an important diagnosis to consider in patients with extrapleural nodules and associated rib or vertebral notching (Tapping & Ettles, 2011). A contrast-enhanced study may help to better characterize these lesions and assist with detection of additional aneurysms, which can involve multiple intercostal arteries (Carr et al., 2013).
There are no established criteria for the treatment of intercostal artery aneurysms. In this case we felt that intervention was justified to reduce the likelihood of aneurysm rupture, thoracic hemorrhage, and sudden death (Dominguez et al., 2002; Hernandez-Velasquez et al., 2016; Arai et al., 2007; Kim et al., 2011; Topel et al., 2004; Carr et al., 2013; Aizawa et al., 2010). Endovascular management of unruptured intercostal artery aneurysms has shown success in a small number of patients to date (Tapping & Ettles, 2011; Bonne et al., 2015; Neuwirth & Singh, 2010; Uzuka et al., 2012). Similar to the technique described by Bonne et al. (2015), we decided on a minimally invasive approach with selective embolization combining microcoils and glue rather than a thoracotomy with ligation, clipping, or excision. Aneurysms are fragile and minimizing the potential for complications such as paraplegia from post-operative hematoma compression is crucial (Aizawa et al., 2010), especially when the aneurysms are in close proximity to the spinal cord as they were in our patient. Since the Adamkiewicz artery did not arise from the target intercostal artery, embolization of the largest aneurysm and two adjacent aneurysms was safely performed. We elected not to treat the other unruptured aneurysms given their sub-centimeter size and location in the lower intercostal arteries where the Adamkiewicz artery most commonly originates. Close follow-up with annual CT angiograms will be used to ensure durable occlusion and to assess for disease progression. Any aneurysms increasing to ≥1 cm in size will be discussed at vascular rounds to weigh the potential benefits of embolization versus the possible risks of complications.
This report demonstrates a unique case of a patient with multiple idiopathic unruptured intercostal artery aneurysms that were successfully managed with endovascular embolization. Appropriate diagnosis and prompt treatment of these rare vascular lesions is essential in preventing the potentially catastrophic consequences of rupture.
Availability of data and materials
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
AF performed the literature review and drafted the manuscript. PO was the consultant vascular surgeon who participated in study design and edited the manuscript. DF was the consultant interventional radiologist who performed the intervention in the case, provided the relevant images, and edited the manuscript. All authors read and approved the final manuscript.
Ethics approval and consent to participate
Waived by Institutional Review Board for case reports.
Consent for publication
Waived by Institutional Review Board for case reports.
The authors declare that they have no competing interests.
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- Aizawa K, Iwashita C, Saito T, Misawa Y (2010) Spontaneous rupture of an intercostal artery in a patient with neurofibromatosis type 1. Interact Cardiovasc Thorac Surg 10(1):128–130View ArticleGoogle Scholar
- Arai K, Sanada J, Kurozumi A, Watanabe T, Matsui O (2007) Spontaneous hemothorax in neurofibromatosis treated with percutaneous embolization. Cardiovasc Intervent Radiol 30(3):477–479View ArticleGoogle Scholar
- Bonne L, Vanhoenacker P, Defreyne L (2015) Embolization of a giant intercostal aneurysm and arteriovenous malformation. Cardiovasc Intervent Radiol 38(5):1352–1355View ArticleGoogle Scholar
- Carr JA, Vadlamudi V, Azher QS (2013) Intercostal artery aneurysmosis. Ann Thorac Surg 96(5):1870–1873View ArticleGoogle Scholar
- Dominguez J, Sancho C, Escalante E, Morera JR, Moya JA, Bernat R (2002) Percutaneous treatment of a ruptured intercostal aneurysm presenting as massive hemothorax in a patient with type I neurofibromatosis. J Thorac Cardiovasc Surg 124(6):1230–1232View ArticleGoogle Scholar
- Gonzalez R, Santolaya R, Prats R, Rodriguez P (2011) Left intercostal aneurysm fistulised to azygos vein as a late complication of thoracic trauma. Eur J Cardiothorac Surg 39(2):276View ArticleGoogle Scholar
- Hernandez-Velasquez D, Monreal-Robles R, Ruiz-Sanchez D, Delgado-Garcia G (2016) Massive hemoptysis due to intercostal artery aneurysm in pulmonary tuberculosis. Pneumologia 65(1):48–50PubMedGoogle Scholar
- Kim HJ, Seon HJ, Choi S, Jang NK (2011) Ruptured aneurysm of intercostal arteriovenous malformation associated with neurofibromatosis type 1: a case report. Cardiovasc Intervent Radiol 34(Suppl 2):S74–S77View ArticleGoogle Scholar
- Neuwirth CA, Singh H (2010) Intercostal artery aneurysm in a child with Kawasaki disease and known coronary artery aneurysms. J Vasc Interv Radiol 21(6):952–953View ArticleGoogle Scholar
- Tapping CR, Ettles DF (2011) Endovascular management of bilateral superior intercostal artery aneurysms following late repair of coarctation of the aorta. Thorac Cardiovasc Surg 59(5):311–313View ArticleGoogle Scholar
- Topel I, Steinbauer M, Paetzel C, Kasprzak PM (2004) Endovascular therapy of a ruptured intercostal artery aneurysm. J Endovasc Ther 11(2):219–221View ArticleGoogle Scholar
- Uzuka T, Ito T, Koyanagi T, Maeda T, Tabuchi M, Kawaharada N, Higami T (2012) Giant intercostal aneurysm complicated by Stanford type B acute aortic dissection in patients with type 1 neurofibromatosis. J Cardiothorac Surg 7:38View ArticleGoogle Scholar