From: Adrenal vein sampling: technique and protocol, a systematic review
Study | Cosyntropin use | Sequential v simultaneous | Selectivity index | Lateralization index |
---|---|---|---|---|
SPARTICUS (Dekkers et al. 2016) | Cont. infusion | sequential | ≥3 | ≥4.0 w/ CSI ≤1 |
Deipolyi (Deipolyi et al. 2015) | Cont. infusion | sequential | ˃3 | ˃4 |
Kocjan (Kocjan et al. 2020) | Cont. infusion | sequential | ˃5 | ˃4 |
Pasternak (Pasternak et al. 2016) | Cont. infusion | sequential | NR | ≥4 |
Ota (Ota et al. 2016) | Bolus 250 μg, sample 15 min later | Simultaneous | ≥5 | NR |
No stim | Simultaneous | ≥1.1 | ≥2.0 | |
Conn (Vonend et al. 2011) | No stim | Sequential | ≥2 | ≥3 |
Wolley (Wolley et al. 2015) | No stim | Sequential | ≥3 | ≥2^ with CSI ≤1 |
Lee (Lee et al. 2020) Bellavance (Bouchard-Bellavance et al. 2020) | Pre and post 250mcg bolus | Simultaneous | ≥3 Pre ≥5 Post | > 2 pre cosyntropin > 4 post cosyntropin |
Teng (Teng et al. 2015) | Pre and post (bolus + infusion) | Sequential | > 2 Pre cosyntropin > 3Post cosyntropin | > 3 Pre cosyntropin > 4 Post cosyntropin |
Webb (Webb et al. 2012) | Pre and post (bolus + infusion) | Simultaneous | > 5 | > 4 |
Japanese Endocrine (Nishikawa et al. 2011) | 250 μg cosyntropin bolus | Simultaneous | ≥5 and ≥ 200 μg/dl cortisol | ≥2.6 or unilateral aldosterone ≥14,000 pg/ml |
Funder (Funder et al. 2016) | No conclusive rec | No conclusive rec | > 5 with cosyntropin > 2 without cosyntropin | > 4 with cosyntropin > 2 without cosyntropin |
Expert Consensus (Rossi et al. 2014) | No conclusive rec | No conclusive rec | ≥3 with cosyntropin ≥2 without cosyntropin | ≥4 with cosyntropin ≥2 without cosyntropin |