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Table 5 Marked heterogeneity of basic procedural aspects of AVS

From: Adrenal vein sampling: technique and protocol, a systematic review

Study Cosyntropin use Sequential v simultaneous Selectivity index Lateralization index
SPARTICUS (Dekkers et al. 2016) Cont. infusion sequential ≥3 ≥4.0 w/ CSI ≤1
Deipolyi (Deipolyi et al. 2015) Cont. infusion sequential ˃3 ˃4
Kocjan (Kocjan et al. 2020) Cont. infusion sequential ˃5 ˃4
Pasternak (Pasternak et al. 2016) Cont. infusion sequential NR ≥4
Ota (Ota et al. 2016) Bolus 250 μg, sample 15 min later Simultaneous ≥5 NR
Miotti (Citton et al. 2015; Miotto et al. 2009) No stim Simultaneous ≥1.1 ≥2.0
Conn (Vonend et al. 2011) No stim Sequential ≥2 ≥3
Wolley (Wolley et al. 2015) No stim Sequential ≥3 ≥2^ with CSI ≤1
Lee (Lee et al. 2020)
Bellavance (Bouchard-Bellavance et al. 2020)
Pre and post 250mcg bolus Simultaneous ≥3 Pre
≥5 Post
> 2 pre cosyntropin
> 4 post cosyntropin
Teng (Teng et al. 2015) Pre and post (bolus + infusion) Sequential > 2 Pre cosyntropin
> 3Post cosyntropin
> 3 Pre cosyntropin
> 4 Post cosyntropin
Webb (Webb et al. 2012) Pre and post (bolus + infusion) Simultaneous > 5 > 4
Japanese Endocrine (Nishikawa et al. 2011) 250 μg cosyntropin bolus Simultaneous ≥5 and ≥ 200 μg/dl cortisol ≥2.6 or unilateral aldosterone ≥14,000 pg/ml
Funder (Funder et al. 2016) No conclusive rec No conclusive rec > 5 with cosyntropin
> 2 without cosyntropin
> 4 with cosyntropin
> 2 without cosyntropin
Expert Consensus (Rossi et al. 2014) No conclusive rec No conclusive rec ≥3 with cosyntropin
≥2 without cosyntropin
≥4 with cosyntropin
≥2 without cosyntropin
  1. NR = not reported. ^Wolley et al. used a modified lateralization index of (Dominant Adrenal Aldosterone/Cortisol)/(IVC Aldosterone/Cortisol) ≥2 and a CSI ≤1