Table 2 Follow-up clinical assessments

VCSS

 Baseline

5.00 (4.00–7.00)

-

-

-

-

-

 2 weeks

3.00 (2.00–5.00)

 < 0.001^*

-

-

-

-

 3 months

1.00 (0.00–3.00)

 < 0.001^*

 < 0.001^*

-

-

-

 6 months

1.00 (0.00 – 2.00)

 < 0.001^*

 < 0.001^*

0.910

-

-

 12 months

1.00 (0.00 – 3.00)

 < 0.001^*

 < 0.001^*

0.369

0.938

-

 36 months

0.00 (0.00 – 1.00)

 < 0.001^*

 < 0.001^*

0.999

0.782

0.256

EQ-5D TTO SG

 Baseline

0.686 (0.430 – 0.890)

-

-

-

-

-

 2 weeks

0.854 (0.700 – 1.00)

 < 0.001^*

-

-

-

-

 3 months

1.00 (0.854 – 1.00)

 < 0.001^*

0.0015^*

-

-

-

 6 months

1.00 (0.854 – 1.00)

 < 0.001^*

0.018^*

0.985

-

-

 12 months

1.00 (0.890 – 1.00)

 < 0.001^*

0.006^*

0.999

0.945

-

 36 months

1.00 (0.838 – 1.00)

 < 0.001^*

0.404

0.553

0.902

0.413

AVVQ

 Baseline

17.1 (11.1–25.4)

-

-

-

-

-

 2 weeks

11.6 (5.90–19.3)

0.0004^*

-

-

-

-

 3 months

4.83 (0.00–9.78)

 < 0.001^*

 < 0.001^*

-

-

-

 6 months

1.81 (0.00–6.68)

 < 0.001^*

 < 0.001^*

0.651

-

-

 12 months

1.45 (0.00–10.7)

 < 0.001^*

 < 0.001^*

0.653

1.00

-

 36 months

1.29 (0.00 – 5.39)

 < 0.001^*

 < 0.001^*

0.579

0.999

0.999

CIVIQ-14

 Baseline

19.64 (12.05–28.57)

-

-

-

-

-

 2 weeks

12.50 (7.14–16.96)

 < 0.001^*

-

-

-

-

 3 months

7.14 (0.00–13.39)

 < 0.001^*

 < 0.001^*

-

-

-

 6 months

5.357 (0.00–12.05)

 < 0.001^*

 < 0.001^*

0.910

-

-

 12 months

5.357 (0.00–10.71)

 < 0.001^*

 < 0.001^*

0.369

0.939

-

 36 months

7.14 (0.00–10.71)

 < 0.001^*

0.0002^*

0.999

0.782

0.255